Matt, a YCS board member, submitted the following experience about his wife Kara:
No problems at all, not even bone pain.
Karen, a YCS board member, submitted the following experience about her husband Mark:
Neulasta can cause bone pain over and above Neupogen. Mark only got Neulasta once, from what I remember, and the pain was bad. My mother (who had breast cancer) got Neulasta once or twice, and it caused her terrible pain, too, mainly in her hips and spine. Neupogen alone caused significant bone pain for Mark. The amount of bone pain probably varies depending both on the individual and on the dose of the drug. I gave him many of the shots. Pre-filled shots are easier to deal with, but even drawing up the drug from a vial isn't so hard when you're shown how to do it and get the hang of it. Sometimes the shots hurt Mark but not always and not usually too bad. Make sure to clean the area thoroughly and rotate the injection site so you don't accidentally cause complications.
If the pain is really bad, make sure your spouse gets strong narcotic painkillers - Tylenol won't do squat to help bone pain, usually. Always insist on pain management!